Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Acetic Acid → 2-(Methylthio)-1H-pyrimidin-4-one
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Acetic Acid | HCID 176 | — |
| 반응물 | Sodium Hydroxide | HCID 14798 | — |
| 반응물 | Thiouracil | HCID 1269845 | — |
| 용매 | Water | HCID 962 | — |
| 용매 | Methyl iodide | HCID 6328 | — |
| 생성물 | 2-(Methylthio)-1H-pyrimidin-4-one | HCID 79823 | — |
반응 단계
To 2-thioxo-2,3-dihydropyrimidin-4(1H)-one (21 g) was added dropwise a solution of sodium hydroxide (13 g) in water (120 mL), iodomethane (11.5 mL) was added thereto, and the mixture was stirred overnight at room temperature. To the reaction mixture was added acetic acid (9.5 mL), and the resulting solid was collected by filtration. The obtained solid was washed with cold water to give the title compound (24 g).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US09187453B2 |
| 출처 데이터셋 | uspto-grants-2015_11 |
| ORD ID | ord-34b66474704041fea99a3a36c45d8f29 |
| 출처 메모 | uspto-grants-2015_11 |