N-(2-(4-nitro-1H-pyrazol-1-yl)ethyl)methanesulfonamide → N-(2-(4-amino-1H-pyrazol-1-yl)ethyl)methanesulfonamide

HRID 714904노트

반응식

HRID 714904 반응식
[N+:1]([C:4]1[CH:5]=[N:6][N:7]([CH2:9][CH2:10][NH:11][S:12]([CH3:15])(=[O:14])=[O:13])[CH:8]=1)([O-])=O>C(O)C.[C].[Pd]>[NH2:1][C:4]1[CH:5]=[N:6][N:7]([CH2:9][CH2:10][NH:11][S:12]([CH3:15])(=[O:14])=[O:13])[CH:8]=1

참가 물질

4

반응물 1

HCID 117840477N-(2-(4-nitro-1H-pyrazol-1-yl)ethyl)methanesulfonamide

생성물 1

HCID 73439022N-(2-(4-amino-1H-pyrazol-1-yl)ethyl)methanesulfonamide수율 112.1%

시약·촉매·용매 2

HCID 178418390HCID 178418390, 화합물촉매HCID 702Ethanol용매

실험 절차

To a solution of N-(2-(4-nitro-1H-pyrazol-1-yl)ethyl)methanesulfonamide (880 mg) obtained in Step A of Example 349 in ethanol (30 mL) was added 10% palladium-carbon (200 mg), and the mixture was stirred at room temperature for 3 hr under hydrogen atmosphere (at normal pressures). The palladium carbon was removed by filtration through Celite, and the solvent was evaporated under reduced pressure to give the title compound (860 mg).

후처리

  1. customThe palladium carbon was removed by filtration through Celite
  2. customthe solvent was evaporated under reduced pressure

출처 및 근거

ORD 기록
ord-844c77046182491c837eb0f12d8ea02a
출처 데이터셋
uspto-grants-2015_11
특허 번호
US09187453B2

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