Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Methyl iodide → Methyl 5-nitrosalicylate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Methyl iodide | HCID 6328 | — |
| 반응물 | 5-Nitrosalicylic acid | HCID 7318 | — |
| 반응물 | Potassium Carbonate | HCID 11430 | — |
| 반응물 | 5-Fluoropyrimidine-2,4-diamine | HCID 255608 | — |
| 생성물 | Methyl 5-nitrosalicylate | HCID 87041 | 77% |
반응 단계
In a manner analogous to the preparation of N2,N4-bis(3-methoxy-4-methoxycarbonyl)phenyl)-5-fluoro-2,4-pyrimidinediamine, 2-hydroxy-5-nitrobenzoic acid (1 g, 5.5 mmol), potassium carbonate (3 g, 22 mmol) and iodomethane (1 mL, 16 mmol) gave methyl 2-hydroxy-5-nitrobenzoate (880 mg, 77%).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08822685B2 |
| 출처 데이터셋 | uspto-grants-2014_09 |
| ORD ID | ord-45ac2add2d5a4a28be66a6508eebb1db |
| 출처 메모 | uspto-grants-2014_09 |