Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 715486생성일: 2026년 10월 25일
L-Alaninol → N-((S)-1-hydroxypropan-2-yl)-2-(1-(5-methyl-6-(2,2,2-trifluoroethoxy)pyridin-3-yl)ethyl)-1-oxo-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-4-carboxamide
https://huagongshe.com/reaction/715486
참여 물질
| 역할 | 이름 | HCID | 투입량 |
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| 반응물 | L-Alaninol | HCID 80307 | — |
| 반응물 | phenyl 2-(1-(5-methyl-6-(2,2,2-trifluoroethoxy)pyridin-3-yl)ethyl)-1-oxo-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-4-carboxylate | HCID 89875412 | — |
| 용매 | Tetrahydrofuran | HCID 8028 | — |
| 생성물 | N-((S)-1-hydroxypropan-2-yl)-2-(1-(5-methyl-6-(2,2,2-trifluoroethoxy)pyridin-3-yl)ethyl)-1-oxo-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-4-carboxamide | HCID 89874554 | 52% |
반응 단계
A mixture of phenyl 2-(1-(5-methyl-6-(2,2,2-trifluoroethoxy)pyridin-3-yl)ethyl)-1-oxo-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-4-carboxylate (20 mg, 0.042 mmol, Intermediate-91, single enantiomer) and (S)-2-aminopropan-1-ol in THF (1.0 mL) is heated at 90° C. overnight. The reaction mixture is concentrated. The residue is purified by preparative LC-MS to give 9.9 mg (52% yield) of the title compound.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 특허 번호 | US09187475B2 |
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| 출처 데이터셋 | uspto-grants-2015_11 |
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| ORD ID | ord-7ceb700fbfbb4ff9b1fdcf5ff47e3e80 |
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| 출처 메모 | uspto-grants-2015_11 |
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