Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Cesium carbonate → 2-Cyclopropyl-4-methoxy-5-nitropyridine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Cesium carbonate | HCID 10796 | — |
| 반응물 | Cyclopropylboronic acid | HCID 2760897 | — |
| 반응물 | 2-Chloro-4-methoxy-5-nitropyridine | HCID 44119673 | — |
| 촉매 | HCID 178418807 | HCID 178418807 | — |
| 용매 | 1,4-Dioxane | HCID 31275 | — |
| 생성물 | 2-Cyclopropyl-4-methoxy-5-nitropyridine | HCID 86717599 | 29.9% |
반응 단계
A mixture of 2-chloro-4-methoxy-5-nitropyridine (1.6 g, 8.48 mmol), cyclopropylboronic acid (1.458 g, 16.97 mmol), PdCl2(dppf)-CH2Cl2 adduct (1.386 g, 1.697 mmol), cesium carbonate (8.29 g, 25.5 mmol), and 1,4-Dioxane (15 mL) were heated using the microwave at 140° C. for 10 minutes. The reaction mixture was purified by normal phase chromatography (ISCO, 120 g silica, 0-3% methanol/DCM) to afford 2-cyclopropyl-4-methoxy-5-nitropyridine as a red solid (492 mg, 28%). MS (m/z) 195.0 (M+H+).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US09187464B2 |
| 출처 데이터셋 | uspto-grants-2015_11 |
| ORD ID | ord-e36e9ffca7724bfbb6da5706df8dac70 |
| 출처 메모 | uspto-grants-2015_11 |