Methyl 4-aminobenzoate → Methyl 4-(2-cyclopentylacetamido)-2-fluorobenzoate

반응식

[CH:1]1([CH2:6][C:7](Cl)=[O:8])[CH2:5][CH2:4][CH2:3][CH2:2]1.[NH2:10][C:11]1[CH:20]=[CH:19][C:14]([C:15]([O:17][CH3:18])=[O:16])=[C:13]([F:21])[CH:12]=1.NC1C=CC(C(OC)=O)=CC=1>>[CH:1]1([CH2:6][C:7]([NH:10][C:11]2[CH:20]=[CH:19][C:14]([C:15]([O:17][CH3:18])=[O:16])=[C:13]([F:21])[CH:12]=2)=[O:8])[CH2:5][CH2:4][CH2:3][CH2:2]1

참가 물질

반응물 3

HCID 12082Methyl 4-aminobenzoate

HCID 3485182Cyclopentylacetyl chloride

HCID 21957875Methyl 4-amino-2-fluorobenzoate

생성물 1

HCID 86701957Methyl 4-(2-cyclopentylacetamido)-2-fluorobenzoate

실험 절차

The title compound was prepared as described in Example 52A, substituting 2-cyclopentylacetyl chloride for 2-cyclopentylacetyl chloride and methyl 4-amino-2-fluorobenzoate for methyl 4-aminobenzoate.

출처 및 근거

ORD 기록: ord-286c9df4e2c2491fab9e1b2fe525b7e2
출처 데이터셋: uspto-grants-2015_11
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US09187472B2

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