참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Ammonium Hydroxide | HCID 14923 | — |
| 반응물 | N-bromobutanimide | HCID 67184 | — |
| 반응물 | Ethyl 3-ethoxy-2-propenoate | HCID 221780 | — |
| 반응물 | tert-Butyl 4-carbamothioylpiperidine-1-carboxylate | HCID 2735648 | — |
| 용매 | 1,4-Dioxane--water (1/1) | HCID 21886435 | — |
| 생성물 | Ethyl 2-(piperidin-4-yl)-1,3-thiazole-5-carboxylate | HCID 86701983 | — |
반응 단계
Ethyl 3-ethoxyacrylate (1.50 g, 10.38 mml) was dissolved in dioxane/water and chilled to −10° C. N-Bromosuccinimide (2.03 g, 11.42 mmol) was added and the mixture was stirred 1 hour at room temperature. tert-Butyl 4-carbamothioylpiperidine-1-carboxylate (2.54 g, 10.38 mmol) was added and the mixture was heated at 100° C. for 1 hour. The reaction mixture was poured into 25 mL saturated ammonium hydroxide and extracted with dichloromethane. The combined organic layers were washed with brine, dried with sodium sulfate, filtered, and concentrated. Normal phase chromatography provided the title compound.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US09187472B2 |
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| 출처 데이터셋 | uspto-grants-2015_11 |
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| ORD ID | ord-329f3457c78540efbaeee55cee310da5 |
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| 출처 메모 | uspto-grants-2015_11 |
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