5-Bromo-2-chloropyrimidine → (-)-4-(4,4-Difluorocyclohexyl)-3-{fluoro[4-(trifluoromethyl)phenyl]methyl}-7,7-dimethyl-2-{1-[5-(methylsulphonyl)pyrimidin-2-yl]piperidin-4-yl}-5,6,7,8-tetrahydroquinolin-5-ol

반응식

Cl[C:2]1[N:7]=[CH:6][C:5]([S:8]([CH3:11])(=[O:10])=[O:9])=[CH:4][N:3]=1.BrC1C=NC(Cl)=NC=1.[F:20][C:21]1([F:67])[CH2:26][CH2:25][CH:24]([C:27]2[C:36]3[CH:35]([O:37]CC4C=CC(OC)=CC=4)[CH2:34][C:33]([CH3:48])([CH3:47])[CH2:32][C:31]=3[N:30]=[C:29]([CH:49]3[CH2:54][CH2:53][NH:52][CH2:51][CH2:50]3)[C:28]=2[CH:55]([F:66])[C:56]2[CH:61]=[CH:60][C:59]([C:62]([F:65])([F:64])[F:63])=[CH:58][CH:57]=2)[CH2:23][CH2:22]1>>[F:67][C:21]1([F:20])[CH2:26][CH2:25][CH:24]([C:27]2[C:36]3[CH:35]([OH:37])[CH2:34][C:33]([CH3:47])([CH3:48])[CH2:32][C:31]=3[N:30]=[C:29]([CH:49]3[CH2:54][CH2:53][N:52]([C:2]4[N:7]=[CH:6][C:5]([S:8]([CH3:11])(=[O:10])=[O:9])=[CH:4][N:3]=4)[CH2:51][CH2:50]3)[C:28]=2[CH:55]([F:66])[C:56]2[CH:61]=[CH:60][C:59]([C:62]([F:64])([F:65])[F:63])=[CH:58][CH:57]=2)[CH2:23][CH2:22]1