Methanol → HCID 89051975, 화합물

HRID 716099노트

반응식

HRID 716099 반응식
C(N[CH:9]1[O:16][C@H:15]([CH2:17][OH:18])[C@@H:13]([OH:14])[C@H:11]([OH:12])[C@@H:10]1[NH:19][CH2:20][C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1)C1C=CC=CC=1.C[OH:28]>>[CH2:20]([NH:19][C@@H:10]([C@H:11]([C@@H:13]([C@@H:15]([CH2:17][OH:18])[OH:28])[OH:14])[OH:12])[CH:9]=[O:16])[C:21]1[CH:22]=[CH:23][CH:24]=[CH:25][CH:26]=1

참가 물질

3

반응물 2

HCID 887MethanolHCID 70874206HCID 70874206, 화합물

생성물 1

HCID 89051975HCID 89051975, 화합물

반응 조건

온도
40 °C

실험 절차

From compound of example 1: to a suspension of N,N′-dibenzyl-1,2-diamino-1,2-dideoxy-D-mannopyranose (10 g) in methanol (30 ml) conc. HCl-solution (4 ml) was gradually added and the mixture was heated to 40° C. for 2-3 hours. The solvent was carefully evaporated, the residue was taken up in methanol and evaporated again 3-4 times. The resulting solid was suspended in ethanol and heated to reflux, the insoluble material was removed by hot filtration, and the filtrate was evaporated to dryness to yield the hydrochloride salt of N-benzyl-2-amino-2-deoxy-D-mannose.

후처리

  1. additionwas gradually added
  2. customThe solvent was carefully evaporated
  3. customevaporated again 3-4 times
  4. temperatureheated
  5. temperatureto reflux
  6. customthe insoluble material was removed by hot filtration
  7. customthe filtrate was evaporated to dryness

출처 및 근거

ORD 기록
ord-b6bcac4e9ccd44d08c937c3350bb6f44
출처 데이터셋
uspto-grants-2015_11
특허 번호
US09187513B2

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