Picolinoyl Chloride Hydrochloride → N-(5-Bromo-4-(trifluoromethyl)thiazol-2-yl)picolinamide

HRID 716621노트

반응식

HRID 716621 반응식
[Br:1][C:2]1[S:6][C:5]([NH2:7])=[N:4][C:3]=1[C:8]([F:11])([F:10])[F:9].Cl.[N:13]1[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=1[C:19](Cl)=[O:20]>C(Cl)Cl>[Br:1][C:2]1[S:6][C:5]([NH:7][C:19](=[O:20])[C:14]2[CH:15]=[CH:16][CH:17]=[CH:18][N:13]=2)=[N:4][C:3]=1[C:8]([F:11])([F:10])[F:9]

참가 물질

4

반응물 2

HCID 135033Picolinoyl Chloride HydrochlorideHCID 157107015-Bromo-4-(trifluoromethyl)-1,3-thiazol-2-amine

생성물 1

HCID 86688229N-(5-Bromo-4-(trifluoromethyl)thiazol-2-yl)picolinamide

시약·촉매·용매 1

HCID 6344Dichloromethane용매2회

실험 절차

To a stirred solution of 5-bromo-4-(trifluoromethyl)thiazol-2-amine (0.204 g, 0.826 mmol) ethyldiisopropylamine (0.36 mL, 2.1 mmol) in methylene chloride (4 mL) at 0° C. was added picolinoyl chloride hydrochloride (0.162 g, 0.908 mmol) and the reaction mixture was stirred at room temperature for 15 h. The reaction mixture was diluted with methylene chloride and washed with saturated NaHCO3, dried, filtered and concentrated under vacuum to give the crude product. The residue was purified by column chromatography eluting with ethyl acetate/hexanes 0 to 30% to give the product.

후처리

  1. washwashed with saturated NaHCO3
  2. customdried
  3. filtrationfiltered
  4. concentrationconcentrated under vacuum

출처 및 근거

ORD 기록
ord-c2f87ae475744f28b6b9d3053afc284e
출처 데이터셋
uspto-grants-2015_11
특허 번호
US09192603B2

반응 노트

불러오는 중…