참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Carbon Tetrachloride | HCID 5943 | — |
| 반응물 | N-bromobutanimide | HCID 67184 | — |
| 반응물 | 2-Bromo-5-methylpyridine | HCID 564216 | — |
| 촉매 | Benzoyl Peroxide | HCID 7187 | — |
| 생성물 | 2-Bromo-5-bromomethylpyridine | HCID 6424660 | 105.4% |
반응 단계
To a solution of 2-Bromo-5-methylpyridine (3.1 g, 17.4 mmol) in carbon tetrachloride (40 mL, 400 mmol) was added benzoyl peroxide (230 mg, 950 μmol) and NBS (3.4 g, 19.2 mmol). The resulting mixture was heated at reflux overnight. The mixture was cooled at 0° C. and the NBS was removed by filtration. The filtrate was concentrated to yield 2-bromo-5-bromomethylpyridine (4.6 g), which was used directly in the next step.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US08822522B2 |
|---|
| 출처 데이터셋 | uspto-grants-2014_09 |
|---|
| ORD ID | ord-cef9ca7e4a984936b559bd23095e3b06 |
|---|
| 출처 메모 | uspto-grants-2014_09 |
|---|
