Carbon Tetrachloride → 2-Bromo-5-bromomethylpyridine

HRID 71668

반응식

HRID 71668 반응식
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([CH3:8])=[CH:4][N:3]=1.C(Cl)(Cl)(Cl)Cl.C1C(=O)N([Br:21])C(=O)C1>C(OOC(=O)C1C=CC=CC=1)(=O)C1C=CC=CC=1>[Br:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][Br:21])=[CH:4][N:3]=1

참가 물질

5

반응물 3

HCID 5943Carbon TetrachlorideHCID 67184N-bromobutanimideHCID 5642162-Bromo-5-methylpyridine

생성물 1

HCID 64246602-Bromo-5-bromomethylpyridine수율 105.4%

시약·촉매·용매 1

HCID 7187Benzoyl Peroxide촉매

반응 조건

온도
0 °C

실험 절차

To a solution of 2-Bromo-5-methylpyridine (3.1 g, 17.4 mmol) in carbon tetrachloride (40 mL, 400 mmol) was added benzoyl peroxide (230 mg, 950 μmol) and NBS (3.4 g, 19.2 mmol). The resulting mixture was heated at reflux overnight. The mixture was cooled at 0° C. and the NBS was removed by filtration. The filtrate was concentrated to yield 2-bromo-5-bromomethylpyridine (4.6 g), which was used directly in the next step.

후처리

  1. temperatureThe resulting mixture was heated
  2. temperatureat reflux overnight
  3. customthe NBS was removed by filtration
  4. concentrationThe filtrate was concentrated

출처 및 근거

ORD 기록
ord-cef9ca7e4a984936b559bd23095e3b06
출처 데이터셋
uspto-grants-2014_09
특허 번호
US08822522B2

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