Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
2-Chlorophenol → 4-Chloro-6-(2-chlorophenoxy)-5-fluoropyrimidine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 2-Chlorophenol | HCID 7245 | — |
| 반응물 | Fluoxastrobin | HCID 11048796 | — |
| 반응물 | 4,6-Dichloro-5-fluoropyrimidine | HCID 11286675 | — |
| 생성물 | 4-Chloro-6-(2-chlorophenoxy)-5-fluoropyrimidine | HCID 11230678 | — |
반응 단계
Fluoxastrobin may further be prepared as described in Scheme 3. Particularly, 4,6-dichloro-5-fluoropyrimidine (5) is reacted with 2-chlorophenol in an appropriate solvent and in the presence of a suitable base to give intermediate 4-chloro-6-(2-chlorophenoxy)-5-fluoropyrimidine (17) which is further reacted with (E)-(5,6-dihydro-1,4,2-dioxazin-3-yl)(2-hydroxyphenyl)methanone O-methyl oxime (13) to give fluoxastrobin.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US09193698B2 |
| 출처 데이터셋 | uspto-grants-2015_11 |
| ORD ID | ord-84fc7b85c1d84a1f9a41fab65b5c04d4 |
| 출처 메모 | uspto-grants-2015_11 |