Sulfuric Acid → Coumaranone

HRID 716728

반응식

HRID 716728 반응식
C([O:4][C:5]1[C:9]2[CH:10]=[CH:11][CH:12]=[CH:13][C:8]=2[O:7][CH:6]=1)(=O)C.OS(O)(=O)=O>CO>[O:7]1[C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][C:9]=2[C:5](=[O:4])[CH2:6]1

참가 물질

4

반응물 2

HCID 1118Sulfuric AcidHCID 27696211-Benzofuran-3-yl acetate

생성물 1

HCID 23556Coumaranone수율 83%

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

To a solution of benzofuran-3-yl acetate (8) (100 g, 1.42 mol) in methanol (350 mL) was added diluted (7.5%) H2SO4 (500 mL) at ambient temperature followed by heating to reflux for 1-3 h. The progress of the reaction was monitored by HPLC analysis. Upon completion of the reaction, the reaction mixture was cooled, filtered, and the slurry was washed with water, and vacuum dried to obtain the product meeting the desired specifications. Yield—83-100%.

후처리

  1. temperatureby heating
  2. temperatureto reflux for 1-3 h
  3. customUpon completion of the reaction
  4. temperaturethe reaction mixture was cooled
  5. filtrationfiltered
  6. washthe slurry was washed with water, and vacuum
  7. customdried
  8. customto obtain the product

출처 및 근거

ORD 기록
ord-69ad0f572a2c40928d1126551b4af5f7
출처 데이터셋
uspto-grants-2015_11
특허 번호
US09193698B2

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