4,4'-Dimethoxybenzil → 2,3-Bis(4-methoxyphenyl)quinoxaline-6-carbonitrile

HRID 716931

반응식

HRID 716931 반응식
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([C:9](=O)[C:10]([C:12]2[CH:17]=[CH:16][C:15]([O:18][CH3:19])=[CH:14][CH:13]=2)=O)=[CH:5][CH:4]=1.[NH2:21][C:22]1[CH:23]=[C:24]([CH:27]=[CH:28][C:29]=1[NH2:30])[C:25]#[N:26]>C(O)(=O)C>[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]2[C:10]([C:12]3[CH:17]=[CH:16][C:15]([O:18][CH3:19])=[CH:14][CH:13]=3)=[N:21][C:22]3[C:29](=[CH:28][CH:27]=[C:24]([C:25]#[N:26])[CH:23]=3)[N:30]=2)=[CH:5][CH:4]=1

참가 물질

4

반응물 2

HCID 710434,4'-DimethoxybenzilHCID 7372853,4-Diaminobenzonitrile

생성물 1

HCID 670419752,3-Bis(4-methoxyphenyl)quinoxaline-6-carbonitrile

시약·촉매·용매 1

HCID 176Acetic Acid용매

실험 절차

Into a 100-mL round-bottom flask, was placed a solution of 1,2-bis(4-methoxyphenyl)ethane-1,2-dione (200 mg, 0.74 mmol, 1.00 equiv) in acetic acid (20 mL), 3,4-diaminobenzonitrile (118.2 mg, 0.89 mmol, 1.20 equiv). The resulting solution was stirred for 1 h at reflux in an oil bath. The reaction was then quenched by the addition of water. The solids were collected by filtration and washed with MeOH. This resulted in 205 mg (71%) of 2,3-bis(4-methoxyphenyl)quinoxaline-6-carbonitrile as a yellow solid.

후처리

  1. customInto a 100-mL round-bottom flask, was placed
  2. temperatureat reflux in an oil bath
  3. customThe reaction was then quenched by the addition of water
  4. filtrationThe solids were collected by filtration
  5. washwashed with MeOH
  6. customThis resulted in 205 mg (71%) of 2,3-bis(4-methoxyphenyl)quinoxaline-6-carbonitrile as a yellow solid

출처 및 근거

ORD 기록
ord-e77c13de211642a395f09dd1a0a16102
출처 데이터셋
uspto-grants-2015_11
특허 번호
US09193693B2

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