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llms.txt · MCP 가이드개인정보처리방침 · 이용약관 · 지원v1.8.0
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Epichlorohydrin → 1-[2-(4-Bromophenyl)-2-propyl]azetidin-3-ol

HRID 717105
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HRID 717105 반응식
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]([NH2:11])([CH3:10])[CH3:9])=[CH:4][CH:3]=1.[CH2:12]([CH:14]1[O:16][CH2:15]1)Cl>CCO>[Br:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]([N:11]2[CH2:15][CH:14]([OH:16])[CH2:12]2)([CH3:9])[CH3:10])=[CH:6][CH:7]=1
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참가 물질

4

반응물 2

HCID 7835EpichlorohydrinHCID 230091162-(4-Bromophenyl)propan-2-amine

생성물 1

HCID 898128241-[2-(4-Bromophenyl)-2-propyl]azetidin-3-ol수율 38.8%

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

1-(4-Bromophenyl)-1-methyl-ethylamine (1 g, 4.67 mmol) and epichlorohydrin (439 μl, 5.6 mmol) in EtOH (15 mL) were heated at 70° C. for 18 h. The reaction mixture was concentrated in vacuo and purified by reverse phase preparative HPLC-MS to obtain 1-[1-(4-bromo-phenyl)-1-methyl-ethyl]-azetidin-3-ol as a white solid (489 mg, 38%).

후처리

  1. concentrationThe reaction mixture was concentrated in vacuo
  2. custompurified by reverse phase preparative HPLC-MS

출처 및 근거

ORD 기록
ord-80d4f3e7eeb847a1a82650c798df9ac5
출처 데이터셋
uspto-grants-2015_11
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US09193689B2

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