Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
3-Butyn-1-OL → 4-((6-Methoxybenzofuran-2-yl)ethynyl)phenyl acetate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 3-Butyn-1-OL | HCID 13566 | — |
| 반응물 | 4-Iodophenylacetate | HCID 141793 | — |
| 반응물 | 4-Bromo-N-(6,6-dimethylbicyclo[3.1.1]heptan-2-yl)benzene sulfonamide | HCID 66614941 | — |
| 반응물 | 2-Ethynyl-6-methoxybenzofuran | HCID 71741760 | — |
| 생성물 | 4-((6-Methoxybenzofuran-2-yl)ethynyl)phenyl acetate | HCID 66614870 | 56% |
반응 단계
When 4-iodophenyl acetate and 2-ethynyl-6-methoxybenzofuran were substituted for 4-bromo-N-(6,6-dimethylbicyclo[3.1.1]heptan-2-yl)benzene sulphonamide and but-3-yn-1-ol respectively in Example 18, Step B, the similar process afforded the title compound in 56% yield, as creamy paste. 1H-NMR (CDCl3) 7.56 (d, 2H, J=8.67 Hz); 7.41 (d, 1H, J=8.58 Hz); 7.10 (d, 2H, J=8.7 Hz); 6.97 (d, 1H, J=1.92 Hz); 6.9 (s, 1H); 6.88 (bd, 1H, J=8.61 Hz); 3.85 (s, 3H); 2.3 (s, 3H).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US09193716B2 |
| 출처 데이터셋 | uspto-grants-2015_11 |
| ORD ID | ord-ca28b73949ec42c2b97f4887a6cd9d3a |
| 출처 메모 | uspto-grants-2015_11 |