Hydrogen Peroxide → HCID 58515933, 화합물

HRID 717831노트

반응식

[Cl:1][C:2]1[N:11]=[CH:10][C:9]([Cl:12])=[CH:8][C:3]=1[C:4]([O:6][CH3:7])=[O:5].FC(F)(F)C(O)=[O:16].OO>>[Cl:1][C:2]1[N+:11]([O-:16])=[CH:10][C:9]([Cl:12])=[CH:8][C:3]=1[C:4]([O:6][CH3:7])=[O:5]

참가 물질

반응물 3

HCID 784Hydrogen Peroxide

HCID 6422Trifluoroacetic acid

HCID 2764318Methyl 2,5-Dichloronicotinate

생성물 1

HCID 58515933HCID 58515933, 화합물수율 99%

반응 조건

온도: 70 °C

실험 절차

A solution of methyl 2,5-dichloronicotinate (15 g, 73 mmol), trifluoroacetic acid (91 mL) and 30% aqueous hydrogen peroxide solution (15 mL) were stirred and heated at 70° C. for 1 hour. Evaporation and purification by flash column chromatography using ethyl acetate in hexanes (0-100%) gave the desired product (16 g, 99%). LCMS calculated for C7H6Cl2NO3 (M+H)+: m/z=222.0. found: 221.8.

후처리

customEvaporation and purification by flash column chromatography

출처 및 근거

ORD 기록: ord-eb3fe48cfd20478b97e96c017f9c91e4
출처 데이터셋: uspto-grants-2015_11
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US09193721B2

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