Ethanolamine → HCID 86713728, 화합물

반응식

Br[CH2:2][C@H:3]1[CH2:7][CH2:6][C@@H:5]([C:8]2[CH:13]=[CH:12][CH:11]=[C:10]([C:14]([F:17])([F:16])[F:15])[CH:9]=2)[O:4]1.[NH2:18][CH2:19][CH2:20][OH:21]>>[F:15][C:14]([F:17])([F:16])[C:10]1[CH:9]=[C:8]([C@H:5]2[O:4][C@@H:3]([CH2:2][NH:18][CH2:19][CH2:20][OH:21])[CH2:7][CH2:6]2)[CH:13]=[CH:12][CH:11]=1

참가 물질

반응물 2

HCID 700Ethanolamine

HCID 68054677HCID 68054677, 화합물

생성물 1

HCID 86713728HCID 86713728, 화합물

실험 절차

2-[({cis-5-[3-(Trifluoromethyl)phenyl]tetrahydrofuran-2-yl}methyl)amino]ethanol was prepared via reaction of cis-2-(bromomethyl)-5-[3-(trifluoromethyl)phenyl]tetrahydrofuran (see H. Ebel et al., PCT Int. Appl., 2010070032, Jun. 24, 2010) with 2-aminoethanol.

출처 및 근거

ORD 기록: ord-2d2054a62fa84ace9f370552afd29437
출처 데이터셋: uspto-grants-2015_11
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US09193726B2

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