Potassium Hydroxide → 2,3,4,5-Tetrahydro-1,4-benzoxazepin-5-one

HRID 718102

반응식

HRID 718102 반응식
[O:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[C:4](=[O:11])[CH2:3][CH2:2]1.[N-:12]=[N+]=[N-].[Na+].[OH-].[K+]>S(=O)(=O)(O)O>[O:1]1[C:10]2[CH:9]=[CH:8][CH:7]=[CH:6][C:5]=2[C:4](=[O:11])[NH:12][CH2:3][CH2:2]1

참가 물질

5

반응물 3

HCID 14797Potassium HydroxideHCID 33557Sodium AzideHCID 68110Chromanone

생성물 1

HCID 3406292,3,4,5-Tetrahydro-1,4-benzoxazepin-5-one

시약·촉매·용매 1

HCID 1118Sulfuric Acid용매2회

반응 조건

온도
0 °C

실험 절차

The chroman-4-one (5.0 g, 33.8 mmol) was dissolved in sulfuric acid (10 mL) and the mixture was cooled at 0° C. Sodium azide (2.88 g, 44.3 mmol) was added portionwise followed by some sulfuric acid (5 mL). The reaction mixture was stirred at room temperature over night. The mixture was then pour into ice-water and basified to pH=7 with potassium hydroxide pellets. This aqueous layer was extracted with ether (twice).

후처리

  1. extractionThis aqueous layer was extracted with ether (twice)

출처 및 근거

ORD 기록
ord-c15779cfa74d436daa5d0b80ddb66e44
출처 데이터셋
uspto-grants-2015_11
특허 번호
US09193749B2

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