2-Benzyloxyaniline → N-(2-(benzyloxy)phenyl)-3-fluoroisonicotinamide

HRID 718103

반응식

HRID 718103 반응식
[F:1][C:2]1[CH:10]=[N:9][CH:8]=[CH:7][C:3]=1[C:4]([OH:6])=O.[CH2:11]([O:18][C:19]1[CH:25]=[CH:24][CH:23]=[CH:22][C:20]=1[NH2:21])[C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1.CSC1C=CC=CC=1OC1C=CC=CC=1N>>[CH2:11]([O:18][C:19]1[CH:25]=[CH:24][CH:23]=[CH:22][C:20]=1[NH:21][C:4](=[O:6])[C:3]1[CH:7]=[CH:8][N:9]=[CH:10][C:2]=1[F:1])[C:12]1[CH:13]=[CH:14][CH:15]=[CH:16][CH:17]=1

참가 물질

4

반응물 3

HCID 2405482-BenzyloxyanilineHCID 3453613-Fluoropyridine-4-carboxylic acidHCID 597837072-(2-Methylsulfanylphenoxy)aniline

생성물 1

HCID 59783597N-(2-(benzyloxy)phenyl)-3-fluoroisonicotinamide

실험 절차

Using Procedure S-3 (Table 5) with 3-fluoroisonicotinic acid and 2-(benzyloxy)aniline the title compound 96 was obtained (4.01 g, 88%) as a white solid. MS (m/z): 323.2 (M+H).

후처리

  1. customwas obtained (4.01 g, 88%) as a white solid

출처 및 근거

ORD 기록
ord-4d38487218034f579c9316165d2340d3
출처 데이터셋
uspto-grants-2015_11
특허 번호
US09193749B2

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