Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
4,4'-Ethylenedianiline → N-Boc-pyrrolidine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 4,4'-Ethylenedianiline | HCID 12138 | — |
| 반응물 | 1(2H)-Quinolinecarboxylic acid, ethyl ester | HCID 27813 | — |
| 반응물 | 1-[(Tert-butoxy)carbonyl]pyrrolidine-2-carboxylic acid | HCID 268472 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 생성물 | N-Boc-pyrrolidine | HCID 643455 | 147.2% |
반응 단계
4,4′-Ethylenedianiline (2.98 g) and pyrrolidine-1,2-dicarboxylic acid 1-tert-butyl ester (7.09 g) were dissolved in DCM (90 mL), and 1-ethoxycarbonyl-1,2-dihydroquinoline (8.38 g) was added. The reaction mixture was stirred at ambient temperature for 3 hours and evaporated under vacuum. Oil was dissolved in ethyl acetate, forming a precipitate, which was collected by vacuum filtration and dried under vacuum, giving 2-[4-(2-{4-[(1-carboxylic acid tert-butyl ester-pyrrolidine-2-carbonyl)-amino]-phenyl}-ethyl)-phenylcarbamoyl]-pyrrolidine-1-carboxylic acid tert-butyl ester (8.30 g, 97%) as a white solid.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08822430B2 |
| 출처 데이터셋 | uspto-grants-2014_09 |
| ORD ID | ord-8e6ab336506e46f299ab7342315879df |
| 출처 메모 | uspto-grants-2014_09 |