Ethanol → HCID 15134190, 화합물

HRID 718690노트

반응식

HRID 718690 반응식
[CH3:1][C:2]1[CH:11]=[CH:10][C:9]2[C:8]([C:12]([OH:14])=[O:13])=[CH:7][CH:6]=[CH:5][C:4]=2[N:3]=1.OS(O)(=O)=O.[CH3:20][CH2:21]O>C(Cl)Cl>[CH3:1][C:2]1[CH:11]=[CH:10][C:9]2[C:8]([C:12]([O:14][CH2:20][CH3:21])=[O:13])=[CH:7][CH:6]=[CH:5][C:4]=2[N:3]=1

참가 물질

5

반응물 3

HCID 702EthanolHCID 1118Sulfuric AcidHCID 3199762-Methyl-5-quinolinecarboxylic acid

생성물 1

HCID 15134190HCID 15134190, 화합물

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

To a slurry of compound 73a (3.1 g, 16 mmol) in EtOH (50 mL) was added concentrated H2SO4 (1.0 mL) and the resultant slurry was refluxed overnight. The homogeneous solution was cooled, diluted with DCM (300 mL), washed with 1N NaOH (1×100 mL), dried (Na2SO4), and concentrated in vacuo to give compound 73b as an off-white solid. Mass spectrum (LCMS, ESI pos.) Calcd. For C13H13NO2: 216.2 (M+H). found 216.2.

후처리

  1. temperaturethe resultant slurry was refluxed overnight
  2. temperatureThe homogeneous solution was cooled
  3. washwashed with 1N NaOH (1×100 mL)
  4. dry with materialdried (Na2SO4)
  5. concentrationconcentrated in vacuo

출처 및 근거

ORD 기록
ord-fddecac2ec004fb285028b74eb0ac7d7
출처 데이터셋
uspto-grants-2015_11
특허 번호
US09193736B2

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