Sodium Azide → 6-(Azidomethyl)phenanthridine

HRID 718739노트

반응식

HRID 718739 반응식
[N-:1]=[N+:2]=[N-:3].[Na+].Br[CH2:6][C:7]1[N:8]=[C:9]2[C:14](=[C:15]3[C:20]=1[CH:19]=[CH:18][CH:17]=[CH:16]3)[CH:13]=[CH:12][CH:11]=[CH:10]2>CC(C)=O>[N:1]([CH2:6][C:7]1[N:8]=[C:9]2[C:14](=[C:15]3[C:20]=1[CH:19]=[CH:18][CH:17]=[CH:16]3)[CH:13]=[CH:12][CH:11]=[CH:10]2)=[N+:2]=[N-:3]

참가 물질

4

반응물 2

HCID 33557Sodium AzideHCID 856742386-(Bromomethyl)phenanthridine

생성물 1

HCID 867124836-(Azidomethyl)phenanthridine

시약·촉매·용매 1

HCID 180Acetone용매

실험 절차

Sodium azide (715 mg, 11.0 mmol) was added to a solution of the bromide 6 (301 mg, 1.10 mmol) in dry acetone (30 mL). The reaction mixture was stirred at ambient temperature for 1 hour, then heated to reflux for 2 hours. The reaction mixture was then allowed to cool to room temperature, the excess sodium azide was filtered off, and the solvent was removed under reduced pressure to yield the crude azide 7 as a light yellow crystalline solid, which was used immediately in the next step without further purification.

후처리

  1. temperatureheated
  2. temperatureto reflux for 2 hours
  3. temperatureto cool to room temperature
  4. filtrationthe excess sodium azide was filtered off
  5. customthe solvent was removed under reduced pressure

출처 및 근거

ORD 기록
ord-db77acfd88524a279d5592adb1161c74
출처 데이터셋
uspto-grants-2015_11
특허 번호
US09194802B2

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