Quinoxaline-5-carbaldehyde → (S)-1,1-diethoxy-N-(quinoxalin-5-ylmethyl)propan-2-amine

HRID 718898노트

반응식

HRID 718898 반응식
[CH2:1]([O:3][CH:4]([O:8][CH2:9][CH3:10])[C@@H:5]([NH2:7])[CH3:6])[CH3:2].[N:11]1[C:20]2[CH:19]=[CH:18][CH:17]=[C:16]([CH:21]=O)[C:15]=2[N:14]=[CH:13][CH:12]=1>>[CH2:1]([O:3][CH:4]([O:8][CH2:9][CH3:10])[C@@H:5]([NH:7][CH2:21][C:16]1[CH:17]=[CH:18][CH:19]=[C:20]2[C:15]=1[N:14]=[CH:13][CH:12]=[N:11]2)[CH3:6])[CH3:2]

참가 물질

3

반응물 2

HCID 582505Quinoxaline-5-carbaldehydeHCID 12398111(2S)-1,1-Diethoxy-2-propanamine

생성물 1

HCID 67075656(S)-1,1-diethoxy-N-(quinoxalin-5-ylmethyl)propan-2-amine수율 78.5%

실험 절차

According to the procedure described in the synthesis method of Compound IX-2, (S)-1,1-diethoxypropan-2-amine (Compound XIX-1) 1.57 g (10.0 mmol) was reacted with quinoxaline-5-carbaldehyde 1.34 g (8.5 mmol) to obtain the title compound 1.93 g (78%).

출처 및 근거

ORD 기록
ord-4802202aeb4e46f2801472fbbc9ca41f
출처 데이터셋
uspto-grants-2015_11
특허 번호
US09193734B2

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