HCID 21896882, 화합물 → HCID 178467018, 화합물

반응식

[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]([NH2:19])[CH:9]([NH2:18])[CH2:10][CH2:11][CH:12]2[CH2:17][CH2:16][CH2:15][CH2:14][CH2:13]2)=[CH:4][CH:3]=1.Cl.[CH2:21]([O:23][C:24]1[CH:34]=[C:33]([O:35][CH3:36])[CH:32]=[CH:31][C:25]=1[C:26](=N)OCC)[CH3:22].ClC1C=CC(C2NC(C3C=CC(OC)=CC=3OCC)=NC2CC2CCCC2)=CC=1>>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([CH:8]2[NH:19][C:26]([C:25]3[CH:31]=[CH:32][C:33]([O:35][CH3:36])=[CH:34][C:24]=3[O:23][CH2:21][CH3:22])=[N:18][CH:9]2[CH2:10][CH2:11][CH:12]2[CH2:17][CH2:16][CH2:15][CH2:14][CH2:13]2)=[CH:6][CH:7]=1

참가 물질

반응물 3

HCID 21896882HCID 21896882, 화합물

HCID 218969061-(4-Chloro-phenyl)-4-cyclohexyl-butane-1,2-diamine

HCID 1784670165-(4-chloro-phenyl)-4-cyclopentylmethyl-2-(2-ethoxy-4-methoxy-phenyl)-4,5-dihydro-1H-imidazole

생성물 1

HCID 178467018HCID 178467018, 화합물

실험 절차

5-(4-Chloro-phenyl)-4-(2-cyclohexyl-ethyl)-2-(2-ethoxy-4-methoxy-phenyl)-4,5-dihydro-1H-imidazole was prepared from 1-(4-chloro-phenyl)-4-cyclohexyl-butane-1,2-diamine and ethyl 2-ethoxy-4-methoxy-benzimidate hydrochloride in an analogous manner as described for the preparation of 5-(4-chloro-phenyl)-4-cyclopentylmethyl-2-(2-ethoxy-4-methoxy-phenyl)-4,5-dihydro-1H-imidazole (Example 9). HR-MS (ES, m/z) observed 441.2309, calculated for C26H34N2O2Cl [(M+H)+]441.2304.