2,3,4-Trichlorobenzenesulfonyl chloride → 2,3,4-trichloro-N-[4-(2-chlorophenyl)-1,3-thiazol-2-yl]benzenesulfonamide

HRID 719349노트

반응식

HRID 719349 반응식
[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8]1[N:9]=[C:10]([NH2:13])[S:11][CH:12]=1.[Cl:14][C:15]1[C:20]([Cl:21])=[C:19]([Cl:22])[CH:18]=[CH:17][C:16]=1[S:23](Cl)(=[O:25])=[O:24]>>[Cl:14][C:15]1[C:20]([Cl:21])=[C:19]([Cl:22])[CH:18]=[CH:17][C:16]=1[S:23]([NH:13][C:10]1[S:11][CH:12]=[C:8]([C:3]2[CH:4]=[CH:5][CH:6]=[CH:7][C:2]=2[Cl:1])[N:9]=1)(=[O:25])=[O:24]

참가 물질

3

반응물 2

HCID 369042,3,4-Trichlorobenzenesulfonyl chlorideHCID 2247644-(2-Chlorophenyl)-1,3-thiazol-2-amine

생성물 1

HCID 102260852,3,4-trichloro-N-[4-(2-chlorophenyl)-1,3-thiazol-2-yl]benzenesulfonamide

실험 절차

The title compound was prepared from 4-(2-chlorophenyl)-1,3-thiazol-2-amine (57 mg) and 2,3,4-trichlorobenzenesulfonyl chloride (76 mg) as described in the synthetic METHOD B to give a white solid (64.8 mg) with purity >90%: MS (pos) m/z 453.3, 455.3, 457.2.

출처 및 근거

ORD 기록
ord-e945e793eabd40aeb005c8f6bf0feb31
출처 데이터셋
uspto-grants-2006_11
특허 번호
US07132436B2

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