4,5-Dichlorothiophene-2-sulfonyl chloride → HCID 10114591, 화합물

HRID 719353노트

반응식

HRID 719353 반응식
Br.[CH3:2][O:3][C:4]1[CH:5]=[C:6]2[C:15](=[CH:16][CH:17]=1)[C:10]1[N:11]=[C:12]([NH2:14])[S:13][C:9]=1[CH2:8][CH2:7]2.[Cl:18][C:19]1[S:20][C:21]([S:25](Cl)(=[O:27])=[O:26])=[CH:22][C:23]=1[Cl:24]>>[Cl:24][C:23]1[CH:22]=[C:21]([S:25]([NH:14][C:12]2[S:13][C:9]3[CH2:8][CH2:7][C:6]4[C:15](=[CH:16][CH:17]=[C:4]([O:3][CH3:2])[CH:5]=4)[C:10]=3[N:11]=2)(=[O:27])=[O:26])[S:20][C:19]=1[Cl:18]

참가 물질

3

반응물 2

HCID 5186224,5-Dichlorothiophene-2-sulfonyl chlorideHCID 28074737-Methoxy-4,5-dihydronaphtho[1,2-d][1,3]thiazol-2-amine hydrobromide

생성물 1

HCID 10114591HCID 10114591, 화합물

실험 절차

The title compound was prepared from 7-methoxy-4,5-dihydronaphtho(1,2-D)(1,3)thiazol-2-amine hydrobromide (85 mg) and 2,3-dichlorothiophene-5-sulfonyl chloride (68 mg) as described in the synthetic METHOD B to give a white solid (16.4 mg) with purity >90%: MS (pos) m/z 447.3, 449.3.

출처 및 근거

ORD 기록
ord-fa79ddbdd8ca4e5193324f5720e8f7c1
출처 데이터셋
uspto-grants-2006_11
특허 번호
US07132436B2

반응 노트

불러오는 중…