Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
4-Bromo-2,5-difluorobenzenesulfonyl Chloride → 4-Bromo-N-{4-[2-chloro-4-(4-chlorophenoxy)phenyl]-1,3-thiazol-2-yl}-2,5-difluorobenzenesulfonamide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 4-Bromo-2,5-difluorobenzenesulfonyl Chloride | HCID 574590 | — |
| 반응물 | 4-[2-Chloro-4-(4-chlorophenoxy)phenyl]-1,3-thiazol-2-amine | HCID 1478576 | — |
| 생성물 | 4-Bromo-N-{4-[2-chloro-4-(4-chlorophenoxy)phenyl]-1,3-thiazol-2-yl}-2,5-difluorobenzenesulfonamide | HCID 10303972 | — |
반응 단계
The title compound was prepared 4-[2-chloro-4-(4-chlorophenoxy)phenyl]-1,3-thiazol-2-amine (91 mg) and 4-bromo-2,5-difluorobenzenesulfonyl chloride (79 mg) as described in the synthetic METHOD B to give a white solid (46.9 mg) with purity >90%: MS (neg) m/z 589.5, 591.5, 593.5; HRMS m/z 589.8745 (calc. of monoisotopic mass for C21 H11 Br Cl2 F2N2 O3 S2 gives 589.8740).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07132436B2 |
| 출처 데이터셋 | uspto-grants-2006_11 |
| ORD ID | ord-879923ea77e24b6da47ac09fd84066f7 |
| 출처 메모 | uspto-grants-2006_11 |