Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Hydrochloric Acid → 8-Iodo-4-oxo-1,4-dihydroquinoline-3-carboxylic acid
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Hydrochloric Acid | HCID 313 | — |
| 반응물 | Ethyl 4-hydroxy-8-iodoquinoline-3-carboxylate | HCID 12403679 | — |
| 용매 | Water | HCID 962 | — |
| 용매 | Sodium Hydroxide | HCID 14798 | — |
| 생성물 | 8-Iodo-4-oxo-1,4-dihydroquinoline-3-carboxylic acid | HCID 21897578 | 81.7% |
반응 단계
8-Iodo-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid ethyl ester (2 g, 5.83 mmol) was suspended in 10% NaOH in water (20 mL). The mixture was stirred under reflux for 1 h. The crude was cooled to room temperature and acidified with concentrated HCl. The solid was filtered off and thoroughly washed with water to afford 8-iodo-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid as a pinkish solid (1.5 g, 81.6%). 1H NMR (DMSO-d6, 400 MHz) δ 7.04 (t, 1H), 8.12–8.16 (m, 2H), 8.71 (s, 1H). Exact mass calculated for C10H6INO3 314.94, found 316 (MH+).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07132426B2 |
| 출처 데이터셋 | uspto-grants-2006_11 |
| ORD ID | ord-645e3334f52f475c91c850d0572af8f9 |
| 출처 메모 | uspto-grants-2006_11 |