Methanol → Penicillamine methyl ester

HRID 719667

반응식

HRID 719667 반응식
[NH2:1][C@H:2]([C:7]([OH:9])=[O:8])[C:3]([SH:6])([CH3:5])[CH3:4].S(Cl)(Cl)=O.[CH3:14]O>>[NH2:1][C@@H:2]([C:3]([SH:6])([CH3:5])[CH3:4])[C:7]([O:9][CH3:14])=[O:8]

참가 물질

4

반응물 3

HCID 887MethanolHCID 24386Thionyl ChlorideHCID 92863L-Penicillamine

생성물 1

HCID 153004Penicillamine methyl ester수율 100%

실험 절차

To a methanol (18 mL, 1.14 M) solution containing L-penicillamine (3.0 g, 20.11 mmol, 1.0 eq) was added thionyl chloride (1.5 mL, 20.7 mmol, 1.03 eq). The resulting mixture was heated to reflux for 18 hr and the solvent removed in vacuo. The resulting clear semi-solid was used in the next step without further purification. Isolated 3.28 g (20.1 mmol, 100% yield).

후처리

  1. temperatureThe resulting mixture was heated
  2. temperatureto reflux for 18 hr
  3. customthe solvent removed in vacuo
  4. customThe resulting clear semi-solid was used in the next step without further purification
  5. customIsolated 3.28 g (20.1 mmol, 100% yield)

출처 및 근거

ORD 기록
ord-bd5e1b8e45af41ca92ca3e05f5afe5be
출처 데이터셋
uspto-grants-2006_11
특허 번호
US07132443B2

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