Sodium Carbonate → 3'-Methyl-biphenyl-3-carboxylic acid ethyl ester

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3′-Methyl-biphenyl-3-carboxylic acid ethyl ester was synthesized as described for 4′-methyl-biphenyl-3-carboxylic acid ethyl ester. Ethyl 3-bromobenzoate (3.83 g, 16.72 mmol, 1 eq.) and 3-methylbenzeneboronic acid (2.5 g, 18.39 mmol, 1.1 eq.) in THF were treated with aqueous sodium carbonate (2M solution, 18.4 mL, 36.78 mmol, 2.2 eq.), palladium(II) acetate (0.37 g, 1.67 mmol, 10 mol %), triphenylphosphine (1.93 g, 7.35 mmol, 4.4×Pd), and copper(I) iodide (0.1 g, catalyst). When complete, the reaction was worked up as described leaving a brown oil.

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