Toluene → HCID 86595355, 화합물

HRID 719739노트

반응식

HRID 719739 반응식
[Cl:1][CH2:2][CH:3]1[CH2:7][CH2:6][CH2:5][N:4]1[C:8]1[CH:13]=[CH:12][C:11]([N+:14]([O-:16])=[O:15])=[CH:10][CH:9]=1.C[C:18]1[NH:19][CH:20]=[CH:21][N:22]=1.[C:23]1(C)C=CC=CC=1>>[Cl-:1].[CH3:23][N+:22]1[CH:21]=[CH:20][N:19]([CH2:2][CH:3]2[CH2:7][CH2:6][CH2:5][N:4]2[C:8]2[CH:13]=[CH:12][C:11]([N+:14]([O-:16])=[O:15])=[CH:10][CH:9]=2)[CH:18]=1

참가 물질

4

반응물 3

HCID 1140TolueneHCID 127492-MethylimidazoleHCID 21901780HCID 21901780, 화합물

생성물 1

HCID 86595355HCID 86595355, 화합물

실험 절차

16.8 g (0.07 mol) of 2-chloromethyl-1-(4-nitrophenyl)pyrrolidine (1), 17.2 g (0.21 mol) of methylimidazole and 70 ml of toluene were refluxed for 9 hours. The solvent was evaporated off and the product was recrystallized from isopropanol and then dried under vacuum. 3 g of yellow crystals (2) were obtained.

후처리

  1. customThe solvent was evaporated off
  2. customthe product was recrystallized from isopropanol
  3. customdried under vacuum

출처 및 근거

ORD 기록
ord-638fa5ddce4e489ea4fa24a0c49d2e8e
출처 데이터셋
uspto-grants-2006_11
특허 번호
US07132543B2

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