Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Ammonia → Modafinil acid
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Ammonia | HCID 222 | — |
| 반응물 | Dimethyl Sulfate | HCID 6497 | — |
| 반응물 | Modafinil acid | HCID 3085267 | — |
| 반응물 | (-)-alpha-Methylbenzylamine (-)-benzhydrylsulphinyl acetate | HCID 68553371 | — |
| 생성물 | Modafinil acid | HCID 3085267 | — |
| 생성물 | HCID 178514057 | HCID 178514057 | — |
반응 단계
The (−)-α-methylbenzylamine-(−)-benzhydrylsulphinyl acetate is then converted to (−)-benzhydrylsulphinylacetic acid by acid hydrolysis. The latter is esterified in the presence of dimethyl sulphate and then converted to amide in the presence of ammonia (gas). The (−) or I (laevorotatory) enantiomer of modafinil is obtained through this process with an overall yield of 5.7% in relation to the (±) modafinil acid, calculated on the basis of the yields corresponding to each stage.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07132570B2 |
| 출처 데이터셋 | uspto-grants-2006_11 |
| ORD ID | ord-200df6927748454982ebd087fd3ac264 |
| 출처 메모 | uspto-grants-2006_11 |