Thionyl Chloride → 2-(4-Chlorophenyl)-2-methylpropanoyl chloride

HRID 720035노트

반응식

HRID 720035 반응식
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]([CH3:13])([CH3:12])[C:9](O)=[O:10])=[CH:4][CH:3]=1.S(Cl)([Cl:16])=O>ClCCl>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]([CH3:13])([CH3:12])[C:9]([Cl:16])=[O:10])=[CH:4][CH:3]=1

참가 물질

4

반응물 2

HCID 24386Thionyl Chloride2회HCID 804062-(4-Chlorophenyl)-2-methylpropionic acid

생성물 1

HCID 135368632-(4-Chlorophenyl)-2-methylpropanoyl chloride

시약·촉매·용매 1

HCID 6344Dichloromethane용매

반응 조건

온도
40 °C

실험 절차

2-(4-chlorophenyl)-2-methyl propionyl chloride was prepared as follows: To a flask containing 2-(4-chlorophenyl)-2-methyl propionic acid (15.0 g, 75.6 mmol) was added thionyl chloride (approx. 6 mL). Dichloromethane (20 mL) was then added before adding an additional portion of thionyl chloride (approx. 12 mL). The reaction was allowed to heat to 40° C. for two hours before cooling to room temperature and concentrating in vacuo (azeotroping with tetrahydrofuran). The resulting acid chloride was used in the following acylation step without further purification or characterization.

후처리

  1. temperaturebefore cooling to room temperature
  2. concentrationconcentrating in vacuo (azeotroping with tetrahydrofuran)
  3. customThe resulting acid chloride was used in the following acylation step without further purification or characterization

출처 및 근거

ORD 기록
ord-ed833fa7d99b4c339465990fbf30bbf0
출처 데이터셋
uspto-grants-2006_11
특허 번호
US07132551B2

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