Triethylamine → HCID 136141672, 화합물

Preparation from the title compound of Example 7 (hydrochloride) (40 mg, 0.128 mmol), (S)-2-Dimethylamino-3-phenyl-propionic acid (30 mg, 0.154 mmol), triethylamine (0.071 mL, 0.512 mmol), and O-(7-azabenzotriazol-1-yl)-N,N,N′,N′-tetramethyluronium hexafluorophosphate (59 mg, 0.154 mmol) in CH2Cl2 (0.4 mL) and N,N-dimethylformamide (0.4 mL) was carried out analogously to Example 11. Silica gel chromatography (elute with 1.5% triethylamine in CH2Cl2 followed by 1.5% triethylamine in 9:1 CH2Cl2:methanol), also in an analogous manner, afforded the freebase of the title compound (46 mg, 0.10 mmol) in three separate batches for a combined 80% yield. Two of the batches were carried on to Examples 71b and 71c respectively. To the third batch (8 mg, 0.018 mmol) was added tetrahydrofuran and 1.2 equivalents of HCl in dioxane (from a 4M stock solution). After evaporation, trituration with diethyl ether and 1:1 CH2Cl2:hexane gave the title compound (6 mg, 0.012 mmol) as a yellow powder in 67% yield for the salt formation.

1. washSilica gel chromatography (elute with 1.5% triethylamine in CH2Cl2 followed by 1.5% triethylamine in 9:1 CH2Cl2:methanol)

ORD 기록

ord-12eeebde859c4fca925ee65a2ffbed61

출처 데이터셋

uspto-grants-2006_11

DOI

10.6084/m9.figshare.5104873.v1

특허 번호

US07132533B2