Potassium Hydroxide → 5,6,7-Trimethoxy-1H-indole-2-carboxylic acid

HRID 720328

반응식

HRID 720328 반응식
[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:9](=[C:10]([O:14][CH3:15])[C:11]=1[O:12][CH3:13])[NH:8][C:7]([C:16]([O:18]C)=[O:17])=[CH:6]2.[OH-].[K+]>CO>[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:9](=[C:10]([O:14][CH3:15])[C:11]=1[O:12][CH3:13])[NH:8][C:7]([C:16]([OH:18])=[O:17])=[CH:6]2

참가 물질

4

반응물 2

HCID 14797Potassium HydroxideHCID 4453649methyl 5,6,7-trimethoxy-1H-indole-2-carboxylate

생성물 1

HCID 8210525,6,7-Trimethoxy-1H-indole-2-carboxylic acid

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

Methyl 5,6,7-trimethoxyindole-2-carboxylate (700 mg) was dissolved in methanol (13 mL), potassium hydroxide powder (450 mg) was added to the solution, and the mixture was stirred for 3 hours under reflux. After allowing the reaction mixture to cool, it was concentrated under reduced pressure, and water was added to the residue. The resultant water layer was washed with ether and then neutralized with diluted hydrochloric acid. Crystals deposited were collected by filtration and dried to obtain the title compound.

후처리

  1. temperatureunder reflux
  2. temperatureto cool
  3. concentrationit was concentrated under reduced pressure, and water
  4. additionwas added to the residue
  5. washThe resultant water layer was washed with ether
  6. filtrationCrystals deposited were collected by filtration
  7. customdried

출처 및 근거

ORD 기록
ord-ef47eda3e0f746f9ab94ee01fb7f597b
출처 데이터셋
uspto-grants-2006_11
특허 번호
US07135473B2

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