Hexahydro-1,4-diazepine → N,N'-bis(5,6,7-trimethoxyindole-2-carbonyl)homopiperazine

HRID 720330

반응식

HRID 720330 반응식
[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:9](=[C:10]([O:14][CH3:15])[C:11]=1[O:12][CH3:13])[NH:8][C:7]([C:16]([OH:18])=O)=[CH:6]2.[NH:19]1[CH2:25][CH2:24][CH2:23][NH:22][CH2:21][CH2:20]1>>[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:9](=[C:10]([O:14][CH3:15])[C:11]=1[O:12][CH3:13])[NH:8][C:7]([C:16]([N:19]1[CH2:25][CH2:24][CH2:23][N:22]([C:16]([C:7]3[NH:8][C:9]4[C:5]([CH:6]=3)=[CH:4][C:3]([O:2][CH3:1])=[C:11]([O:12][CH3:13])[C:10]=4[O:14][CH3:15])=[O:18])[CH2:21][CH2:20]1)=[O:18])=[CH:6]2

참가 물질

3

반응물 2

HCID 68163Hexahydro-1,4-diazepineHCID 8210525,6,7-Trimethoxy-1H-indole-2-carboxylic acid

생성물 1

HCID 21891614N,N'-bis(5,6,7-trimethoxyindole-2-carbonyl)homopiperazine

실험 절차

5,6,7-Trimethoxyindole-2-carboxylic acid (300 mg) and homopiperazine (60 mg) were reacted in the same manner as in Preparation Example 37 to obtain the title compound.

출처 및 근거

ORD 기록
ord-392f872bb6ae4481bdcdcb41aa502896
출처 데이터셋
uspto-grants-2006_11
특허 번호
US07135473B2

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