2-bromo-N-ethylacetamide → HCID 135828226, 화합물

HRID 720451노트

반응식

HRID 720451 반응식
[NH2:1][C:2]1[C:7]([C:8]#[N:9])=[C:6]([C:10]2[CH:15]=[CH:14][C:13]([OH:16])=[CH:12][CH:11]=2)[C:5]([C:17]#[N:18])=[C:4]([SH:19])[N:3]=1.[CH2:20]([NH:22][C:23](=[O:26])[CH2:24]Br)[CH3:21].C([O-])(O)=O.[Na+]>CN(C=O)C>[NH2:1][C:2]1[N:3]=[C:4]([S:19][CH2:24][C:23]([NH:22][CH2:20][CH3:21])=[O:26])[C:5]([C:17]#[N:18])=[C:6]([C:10]2[CH:11]=[CH:12][C:13]([OH:16])=[CH:14][CH:15]=2)[C:7]=1[C:8]#[N:9]

참가 물질

5

반응물 3

HCID 2207922-bromo-N-ethylacetamideHCID 516892Sodium BicarbonateHCID 178510481HCID 178510481, 화합물

생성물 1

HCID 135828226HCID 135828226, 화합물

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

At RT 0.76 g (2 mmol) of 2-amino-4-(4-hydroxyphenyl)-6-sulfanyl-3,5-pyridinedicarbonitrile and 0.5 g (3 mmol) of N-ethylbromoacetamide are stirred in 5 ml of DMF together with 0.34 g (4 mmol) of NaHCO3 for 4 hours. After dilution with water, the mixture is extracted with ethyl acetate and the ethyl acetate phase is dried with MgSO4 and concentrated under reduced pressure. The solid residue obtained after concentration is stirred with methanol. The crystals are filtered off with suction and dried under reduced pressure.

후처리

  1. extractionAfter dilution with water, the mixture is extracted with ethyl acetate
  2. dry with materialthe ethyl acetate phase is dried with MgSO4
  3. concentrationconcentrated under reduced pressure
  4. customThe solid residue obtained
  5. concentrationafter concentration
  6. filtrationThe crystals are filtered off with suction
  7. customdried under reduced pressure

출처 및 근거

ORD 기록
ord-7ac6ea661a9442ca9e2a1260ec8ddce6
출처 데이터셋
uspto-grants-2006_11
특허 번호
US07135486B1

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