Boron tribromide → HCID 59611582, 화합물

HRID 72055노트

반응식

HRID 72055 반응식
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[S:12][C:11]3[CH:13]=[C:14]([O:17]C)[CH:15]=[CH:16][C:10]=3[CH:9]=2)=[CH:4][CH:3]=1.B(Br)(Br)Br>>[Br:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[S:12][C:11]3[CH:13]=[C:14]([OH:17])[CH:15]=[CH:16][C:10]=3[CH:9]=2)=[CH:4][CH:3]=1

참가 물질

3

반응물 2

HCID 25134Boron tribromideHCID 167197572-(4-Bromophenyl)-6-methoxybenzo[b]thiophene

생성물 1

HCID 59611582HCID 59611582, 화합물수율 88%

실험 절차

To a stirred solution of 2-(4-bromo-phenyl)-6-methoxy-benzo[b]thiophene (80 mg, 0.25 mmol) was added BBr3 (0.5 mL of 1 M in DCM, 0.5 mmol) at 0° C. The mixture was stirred for 3 hours at ambient temperature. DCM was removed under vacuum, and the residue was dissolved in ethyl acetate (30 mL). The organic layer was washed with NaHCO3 solution, water and brine, dried over Na2SO4, filtered and concentrated in vacuo. The obtained residue was treated with hexane to give the product (67 mg, 88%). m/z 303.0, 305.0 (M−H)−.

후처리

  1. customDCM was removed under vacuum
  2. dissolutionthe residue was dissolved in ethyl acetate (30 mL)
  3. washThe organic layer was washed with NaHCO3 solution, water and brine
  4. dry with materialdried over Na2SO4
  5. filtrationfiltered
  6. concentrationconcentrated in vacuo
  7. additionThe obtained residue was treated with hexane

출처 및 근거

ORD 기록
ord-163ffb7babc54b949918ee4125254491
출처 데이터셋
uspto-grants-2014_09
특허 번호
US08822430B2

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