Uracil → HCID 178474113, 화합물

HRID 720656

반응식

HRID 720656 반응식
FC(F)(F)C([NH:5]C1C=CC(CC(O)=O)=CC=1)=O.[C:18]([NH:21][C:22]1[CH:27]=[CH:26][C:25](CC(O)=O)=[CH:24][CH:23]=1)(=[O:20])[CH3:19].N1C=CC(=O)NC1=O>>[N:5].[C:18]([NH:21][C:22]1[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=1)(=[O:20])[CH3:19]

참가 물질

4

반응물 3

HCID 1174Uracil2회HCID 2018ActaritHCID 825287{4-[(Trifluoroacetyl)amino]phenyl}acetic acid

생성물 1

HCID 178474113HCID 178474113, 화합물

실험 절차

This compound was prepared by a method similar to that described in example 11 (method 1) except that [4-(2,2,2-trifluoro-acetylamino)-phenyl]-acetic acid (prepared by the method of K. D. Janda et al, as described in J. Amer. Chem. Soc. 1991, 113, 291) was used in place of (4-acetylamino-phenyl)-acetic acid. A mixture of products arising from mono-alkylation at the 1 position of the 1H-pyrimidine-2,4-dione and bis-alkylation at both the 1 position of the 1H-pyrimidine-2,4-dione and acetanilide nitrogen were obtained. When this mixture of compounds was directly subjected to the conditions used to effect cyclization to the xanthine the trifluoroacetyl groups were removed by hydrolysis. A 2:1 mixture of 8-(amino-benzyl)-3-butyl-1-(2-fluorobenzyl)-3,7-dihydro-purine-2,6-dione and 3-butyl-8-(4-butylamino-benzyl)-1-(2-fluorobenzyl)-3,7-dihydro-purine-2,6-dione was obtained which was separated by chromatography using silica gel eluted with 96:4 chloroform/methanol. MS, m/z(M+)=421.1914.

후처리

  1. customThis compound was prepared by a method similar to
  2. customprepared by the method of K
  3. additionA mixture of products

출처 및 근거

ORD 기록
ord-092549754f244f38977d3dbefa233536
출처 데이터셋
uspto-grants-2006_11
특허 번호
US07135475B2

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