HCID 178424903, 화합물 → HCID 178465153, 화합물

HRID 72075

반응식

HRID 72075 반응식
CC1C(C)=C(C(C2N=CNC=2)C)C=CC=1.[CH3:16][CH2:17][NH:18][C:19]([C@H:21]1[N:25]([C:26]([C@@H:28]([NH:36][C:37]([C@@H:39]([NH:44][C:45]([C@H:47]([NH:52][C:53]([C@@H:55]([NH:64][C:65]([C@@H:67]([NH:70][C:71]([C@@H:73]([NH:84][C:85]([C@@H:87]([NH:94][C:95]([C@H:97]2[NH:102][C:100](=[O:101])[CH2:99][CH2:98]2)=[O:96])[CH2:88][C:89]2[N:93]=[CH:92][NH:91][CH:90]=2)=[O:86])[CH2:74][C:75]2[C:79]3[CH:80]=[CH:81][CH:82]=[CH:83][C:78]=3[NH:77][CH:76]=2)=[O:72])[CH2:68][OH:69])=[O:66])[CH2:56][C:57]2[CH:58]=[CH:59][C:60]([OH:63])=[CH:61][CH:62]=2)=[O:54])[CH2:48][CH:49]([CH3:51])[CH3:50])=[O:46])[CH2:40][CH:41]([CH3:43])[CH3:42])=[O:38])[CH2:29][CH2:30][CH2:31][NH:32][C:33]([NH2:35])=[NH:34])=[O:27])[CH2:24][CH2:23][CH2:22]1)=[O:20].CC(O)=O>O>[CH3:16][CH2:17][NH:18][C:19]([C@H:21]1[N:25]([C:26]([C@@H:28]([NH:36][C:37]([C@@H:39]([NH:44][C:45]([C@H:47]([NH:52][C:53]([C@@H:55]([NH:64][C:65]([C@@H:67]([NH:70][C:71]([C@@H:73]([NH:84][C:85]([C@@H:87]([NH:94][C:95]([C@H:97]2[NH:102][C:100](=[O:101])[CH2:99][CH2:98]2)=[O:96])[CH2:88][C:89]2[N:93]=[CH:92][NH:91][CH:90]=2)=[O:86])[CH2:74][C:75]2[C:79]3[CH:80]=[CH:81][CH:82]=[CH:83][C:78]=3[NH:77][CH:76]=2)=[O:72])[CH2:68][OH:69])=[O:66])[CH2:56][C:57]2[CH:62]=[CH:61][C:60]([OH:63])=[CH:59][CH:58]=2)=[O:54])[CH2:48][CH:49]([CH3:51])[CH3:50])=[O:46])[CH2:40][CH:41]([CH3:43])[CH3:42])=[O:38])[CH2:29][CH2:30][CH2:31][NH:32][C:33]([NH2:35])=[NH:34])=[O:27])[CH2:24][CH2:23][CH2:22]1)=[O:20]

참가 물질

4

반응물 2

HCID 178424903HCID 178424903, 화합물HCID 178476396HCID 178476396, 화합물

생성물 1

HCID 178465153HCID 178465153, 화합물

시약·촉매·용매 1

HCID 962Water용매

실험 절차

Beagle dogs (10-15 Kg) were sedated with medetomidine (80 μg/kg) and an endoscope was inserted via the mouth, oesophagus and stomach into the duodenum. The test solutions (10 ml), comprising leuprolide acetate (Mallinckrodt Inc, St. Louis, Mo.) with or without enhancer reconstituted in deionised water were administered intraduodenally via the endoscope. Following removal of the endoscope, sedation was reversed using atipamezole (400 g/kg). The parenteral reference solutions comprising 1 mg Leuprolide reconstituted in 0.5 ml sterile water were administered intravenously and subcutaneously respectively.

후처리

  1. customremoval of the endoscope, sedation

출처 및 근거

ORD 기록
ord-c56349691f814300a4dc80ff72642234
출처 데이터셋
uspto-grants-2014_09
특허 번호
US08828431B2

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