1-Bromo-4-fluorobenzene → 4-Fluoro-4'-methoxybiphenyl

HRID 72082노트

반응식

HRID 72082 반응식
[F:1][C:2]1[CH:7]=[CH:6][C:5](Br)=[CH:4][CH:3]=1.[CH3:9][O:10][C:11]1[CH:16]=[CH:15][C:14](B(O)O)=[CH:13][CH:12]=1>>[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:14]2[CH:15]=[CH:16][C:11]([O:10][CH3:9])=[CH:12][CH:13]=2)=[CH:4][CH:3]=1

참가 물질

3

반응물 2

HCID 99931-Bromo-4-fluorobenzeneHCID 201262(4-Methoxyphenyl)boronic acid

생성물 1

HCID 27589974-Fluoro-4'-methoxybiphenyl수율 89%

실험 절차

From 4-fluoro-bromobenzene and 4-methoxyphenyl boronic acid, yield 89%; mp 92-94° C. (lit.,2 94-96° C.); IR: 1504, 1276 and 1041; 1H NMR (400 MHz; CDCl3): 7.53-7.46 (4H, m), 7.11 (2H, t, J 8.7), 6.98 (2H, d, J 8.8) and 3.85 (3H, s); m/z (EI) 202 (95%, M+), 159 (100), 133 (90) and 69 (40)(Found: M+, 202.079. C13H11FO requires M, 202.079).

후처리

  1. custommp 92-94° C. (lit.,2 94-96° C.)

출처 및 근거

ORD 기록
ord-9c0b1640985042b3b9aac8440b7eb3b9
출처 데이터셋
uspto-grants-2014_09
특허 번호
US08828902B2

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