4-Bromoanisole → 4-Methoxybiphenyl

HRID 72087

반응식

HRID 72087 반응식
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6](Br)=[CH:5][CH:4]=1.[C:10]1(B(O)O)[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1>>[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=2)=[CH:5][CH:4]=1

참가 물질

3

반응물 2

HCID 77304-BromoanisoleHCID 66827Phenylboronic Acid

생성물 1

HCID 119434-Methoxybiphenyl수율 94%

실험 절차

From 4-methoxy-bromobenzene and phenyl boronic acid, yield 94%; mp 85-88° C. (lit.,8 90-91° C.); IR: 1604, 1582, 1520, 1486 and 1286; 1H NMR (400 MHz; CDCl3): 7.57-7.52 (4H, m), 7.42 (2H, t, J 7.9), 7.31 (1H, t, J 7.3), 6.99 (2H, d, J 8.8) and 3.86 (3H, s); 13C NMR (CDCl3): 159.1, 140.8, 133.8, 128.7, 128.1, 126.6, 115.7, 114.2 and 55.3; m/z (EI) 184 (100%, M+), 141 (60) and 69 (40)(Found: M+, 184.088. C13H12O2 requires M, 184.088).

후처리

  1. custommp 85-88° C. (lit.,8 90-91° C.)

출처 및 근거

ORD 기록
ord-dfea3966b339431e98688166da1a238d
출처 데이터셋
uspto-grants-2014_09
특허 번호
US08828902B2

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