Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
4-Methylmorpholine → Ethyl 3-(2-{(tert-butoxycarbonyl)amino}acetylamino)propionate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 4-Methylmorpholine | HCID 7972 | — |
| 반응물 | Dicyclohexylcarbodiimide | HCID 10868 | — |
| 반응물 | N-(tert-butoxycarbonyl)glycine | HCID 78288 | — |
| 반응물 | beta-Alanine, ethyl ester, hydrochloride | HCID 458475 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 생성물 | Ethyl 3-(2-{(tert-butoxycarbonyl)amino}acetylamino)propionate | HCID 21893946 | 62% |
반응 단계
A solution of β-alanine ethyl ester hydrochloride salt (5) (3.07 g; 0.02 mmol), N-(tertbutoxycarbonyl)glycine (3.5 g; 0.02 mmol), DCCI (4.12 g; 0.02 mmol) and 4-methylmorpholine (2.2 ml) in dichloromethane (60 ml) was stirred overnight under argon atmosphere at ambient temperature. After filtration the residue was purified by flash chromatography eluting with dichloromethane/ethanol (96/4) to give ethyl 3-[(2-tertbutoxycarbonylaminoacetyl)amino]propanoate (6).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07135502B1 |
| 출처 데이터셋 | uspto-grants-2006_11 |
| ORD ID | ord-a2f12b02ca7c40afb4b1912884e48d63 |
| 출처 메모 | uspto-grants-2006_11 |