1-Piperidinepropanoic acid → N-[(5S)-3-(3-piperidinopropanoylamino)-9,10,11-trimethoxy-6,7-dihydro-5H-dibenzo[a,c]cyclohepten-5-yl]acetamide

HRID 720948

반응식

HRID 720948 반응식
[NH2:1][C:2]1[CH:3]=[CH:4][C:5]2[C:11]3[C:12]([O:20][CH3:21])=[C:13]([O:18][CH3:19])[C:14]([O:16][CH3:17])=[CH:15][C:10]=3[CH2:9][CH2:8][C@H:7]([NH:22][C:23](=[O:25])[CH3:24])[C:6]=2[CH:26]=1.[N:27]1([CH2:33][CH2:34][C:35](O)=[O:36])[CH2:32][CH2:31][CH2:30][CH2:29][CH2:28]1>>[N:27]1([CH2:33][CH2:34][C:35]([NH:1][C:2]2[CH:3]=[CH:4][C:5]3[C:11]4[C:12]([O:20][CH3:21])=[C:13]([O:18][CH3:19])[C:14]([O:16][CH3:17])=[CH:15][C:10]=4[CH2:9][CH2:8][C@H:7]([NH:22][C:23](=[O:25])[CH3:24])[C:6]=3[CH:26]=2)=[O:36])[CH2:32][CH2:31][CH2:30][CH2:29][CH2:28]1

참가 물질

3

반응물 2

HCID 1177821-Piperidinepropanoic acidHCID 57174210N-[(5S)-3-amino-9,10,11-trimethoxy-6,7-dihydro-5H-dibenzo[a,c]cyclohepten-5-yl]acetamide

생성물 1

HCID 57034655N-[(5S)-3-(3-piperidinopropanoylamino)-9,10,11-trimethoxy-6,7-dihydro-5H-dibenzo[a,c]cyclohepten-5-yl]acetamide수율 61%

실험 절차

Using an analogous procedure to that described for Example 21, N-[(5S)-3-amino-9,10,11-trimethoxy-6,7-dihydro-5H-dibenzo[a,c]cyclohepten-5-yl]acetamide was reacted with 1-piperidinepropionic acid to give N-[(5S)-3-(3-piperidinopropanoylamino)-9,10,11-trimethoxy-6,7-dihydro-5H-dibenzo[a,c]cyclohepten-5-yl]acetamide.

출처 및 근거

ORD 기록
ord-bf7ea990e95e4412af08798b0a89899a
출처 데이터셋
uspto-grants-2006_11
특허 번호
US07135502B1

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