Methanol → Methyl 12-aminododecanoate--hydrogen chloride (1/1)

HRID 72097

반응식

HRID 72097 반응식
O=S(Cl)[Cl:3].[NH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][C:17]([OH:19])=[O:18].[CH3:20]O>>[ClH:3].[CH3:20][O:18][C:17](=[O:19])[CH2:16][CH2:15][CH2:14][CH2:13][CH2:12][CH2:11][CH2:10][CH2:9][CH2:8][CH2:7][CH2:6][NH2:5]

참가 물질

4

반응물 3

HCID 887MethanolHCID 24386Thionyl ChlorideHCID 6966112-Aminododecanoic Acid

생성물 1

HCID 19372000Methyl 12-aminododecanoate--hydrogen chloride (1/1)수율 60%

실험 절차

MeOH (40 ml) was cooled to 0-5° C., and SOCl2 (4 ml) was added drop wise with stirring during 30 minutes. 12-Aminododecanoic acid (3 g, 13.9 mmol) was added and the resulting suspension was stirred at 0-5° C. while the ice in cooling bath melted and allowed to warm to room temperature during 16 hours. The mixture was filtered and the solid was dried by suction to afford 2.23 g (60%) of 12-aminododecanoic acid methyl ester hydrochloride. From the mother liquor a further batch of 0.92 g (25%) was isolated.

후처리

  1. temperaturein cooling bath
  2. filtrationThe mixture was filtered
  3. customthe solid was dried by suction

출처 및 근거

ORD 기록
ord-e32181550fca4c63a91217fa119ba77b
출처 데이터셋
uspto-grants-2014_09
특허 번호
US08828923B2

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