Toluene → N-{4-[(6,7-Dimethoxy-4-quinolyl)oxy]phenyl}-{[(diisopropylamino)carbonyl]amino}methanethioamide

HRID 721819노트

반응식

HRID 721819 반응식
C(N(C(C)C)C(Cl)=O)(C)C.[CH:11]([N:14]([C:18]([N:20]=[C:21]=[S:22])=[O:19])[CH:15]([CH3:17])[CH3:16])([CH3:13])[CH3:12].[CH3:23][O:24][C:25]1[CH:26]=[C:27]2[C:32](=[CH:33][C:34]=1[O:35][CH3:36])[N:31]=[CH:30][CH:29]=[C:28]2[O:37][C:38]1[CH:44]=[CH:43][C:41]([NH2:42])=[CH:40][CH:39]=1.C1(C)C=CC=CC=1>C(O)C>[CH:11]([N:14]([C:18]([N:20]=[C:21]=[S:22])=[O:19])[CH:15]([CH3:17])[CH3:16])([CH3:12])[CH3:13].[CH3:23][O:24][C:25]1[CH:26]=[C:27]2[C:32](=[CH:33][C:34]=1[O:35][CH3:36])[N:31]=[CH:30][CH:29]=[C:28]2[O:37][C:38]1[CH:39]=[CH:40][C:41]([NH:42][C:21]([NH:20][C:18]([N:14]([CH:15]([CH3:17])[CH3:16])[CH:11]([CH3:12])[CH3:13])=[O:19])=[S:22])=[CH:43][CH:44]=1

참가 물질

7

반응물 4

HCID 1140TolueneHCID 87890Diisopropylcarbamoyl chlorideHCID 115945434-[(6,7-Dimethoxyquinolin-4-yl)oxy]anilineHCID 13441033(Diisopropylamino)methanoyl isothiocyanate

생성물 2

HCID 13441033(Diisopropylamino)methanoyl isothiocyanateHCID 21890681N-{4-[(6,7-Dimethoxy-4-quinolyl)oxy]phenyl}-{[(diisopropylamino)carbonyl]amino}methanethioamide수율 62%

시약·촉매·용매 1

HCID 702Ethanol용매2회

실험 절차

(Diisopropylamino)methanoyl isothiocyanate was prepared using commercially available N,N-diisopropylcarbamic chloride (80 mg) as a starting compound according to the description of the literature. (Diisopropylamino)methanoyl isothiocyanate was dissolved in ethanol (1 ml) to prepare a solution. 4-[(6,7-Dimethoxy-4-quinolyl)oxy]aniline (50 mg), toluene (5 ml), and ethanol (1 ml) were added to the solution, and the mixture was stirred at room temperature for 2 hr. The reaction solution was concentrated, and the residue was purified by chromatography on silica gel using chloroform/acetone for development to give the title compound (50 mg, yield 62%).

후처리

  1. customto prepare a solution
  2. concentrationThe reaction solution was concentrated
  3. customthe residue was purified by chromatography on silica gel

출처 및 근거

ORD 기록
ord-dadf39e819424551895eefc7151b734e
출처 데이터셋
uspto-grants-2006_11
특허 번호
US07135466B2

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