(1S,4S)-2-oxa-5-azabicyclo(2.2.1)heptane hydrochloride → HCID 86652438, 화합물
반응식
[Cl:1][C:2]1[N:3]=[C:4]([N:12]2[CH2:17][CH2:16][O:15][CH2:14][C@@H:13]2[CH3:18])[C:5]2[N:10]([CH3:11])[N:9]=[CH:8][C:6]=2[N:7]=1.Cl.[C@H]12C[C@H](NC1)CO2>>[Cl:1][C:2]1[N:3]=[C:4]([N:12]2[CH2:17][C@@H:16]3[CH2:18][C@H:13]2[CH2:14][O:15]3)[C:5]2[N:10]([CH3:11])[N:9]=[CH:8][C:6]=2[N:7]=1참가 물질
3
실험 절차
This compound was prepared in an analogous fashion to (S)-4-(5-chloro-1-methyl-1H-pyrazolo[4,3-d]pyrimidin-7-yl)-3-methylmorpholine, using (1S,4S)-2-oxa-5-azabicyclo[2.2.1]heptane hydrochloride salt as the starting material. 1H NMR (CDCl3, 500 MHz) δ ppm 7.96 (s, 1H), 5.15 (s, 1H), 4.76 (s, 1H), 4.20 (s, 3H), 4.13 (d, J=8.1 Hz, 1H), 3.97 (ddd, J=7.0 Hz, 4.7 Hz, 1.5 Hz, 2H), 3.69 (d, J=9.5 Hz, 1H), 2.09 to 1.94 (m, 2H); LC-MS m/z (method A)=266.1 [M+H]+, RT=1.37 min.
출처 및 근거
- ORD 기록
- ord-ec5e598072a54277b4aeb4fd5669ccb5
- 출처 데이터셋
- uspto-grants-2014_09
- DOI