Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Potassium Carbonate → Dimethyl-[1-(3-methyl-4-nitrophenyl)pyrrolidin-3-yl]amine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Potassium Carbonate | HCID 11430 | — |
| 반응물 | 5-Fluoro-2-nitrotoluene | HCID 94956 | — |
| 반응물 | 3-(Dimethylamino)pyrrolidine | HCID 2758519 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 생성물 | Dimethyl-[1-(3-methyl-4-nitrophenyl)pyrrolidin-3-yl]amine | HCID 68977058 | — |
반응 단계
A mixture of 4-fluoro-2-methyl-1-nitrobenzene (13.6 g), dimethylpyrrolidin-3-ylamine (10.0 g), potassium carbonate (12 g) and DMF (100 mL) was stirred at room temperature for 4 hours. The reaction mixture was partitioned between water and ethyl acetate. The organic phase was dried and concentrated. The product with the molecular weight of 249.32 (C13H19N3O2) was obtained in this way; MS (ESI): 250 (M+H+).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08828991B2 |
| 출처 데이터셋 | uspto-grants-2014_09 |
| ORD ID | ord-0875dc4f41854179839123d1593d5957 |
| 출처 메모 | uspto-grants-2014_09 |